Publications & Presentations in the therapeutic area :

A novel integrated RNAi/viral dynamics systems pharmacology model

Maanen E. v., Brady K., Steeg T.v. and Graaf P.v.d., A novel integrated RNAi/viral dynamics systems pharmacology model to predict clinical efficacy of viral vector delivery of siRNA for the treatment of HCV. Noordwijkerhout.(2010)

Modeling of alpha interferon response

Benson N., Jongh J.d, Duckworth J.D., Jones H.M., Pertinez H.E., Rawal J.K., Steeg T.J. v. and Graaf P.H.v.d., Pharmacokinetic-pharmacodynamic modeling of alpha interferon response induced by a Toll-like 7 receptor agonist in mice, Antimicrob Agents Chemother., 54(3): 1179-1185. 2010. [Link to publication]

Explaining variability in ciclosporin exposure

Press R.R., Ploeger B.A., Hartigh J.d, Straaten T.v.d., van Pelt H., Danhof M., Fijter H.d. and Guchelaar H.J., Explaining variability in ciclosporin exposure in adult kidney transplant recipients, Eur J Clin Pharmacol., 66(6): 579-590. Epub 2010 Mar 2031., 2010. [Link to publication]

Is Calcineurin activity useful as a biomarker to optimize cyclosporine a therapy in renal transplant recipients?

Press R.R., Rossum H.H. v., Ploeger B.A., Hartigh J.d.,  Pelt J.v., Guchelaar H.J., Fijter J.W.d. and Danhof M., Is Calcineurin activity useful as a biomarker to optimize cyclosporine a therapy in renal transplant recipients? PAGE.(2009).[Link to publication]

Pharmacokinetics of amoxicillin

Muller A.E., Oostvogel P.M., Jongh J.d., Mouton J.W., Steegers E.A., Dorr P.J., Danhof M. and Voskuyl R.A., Pharmacokinetics of amoxicillin in maternal, umbilical cord, and neonatal sera, Antimicrob Agents Chemother, 53(4): 1574-1580, 2009. [Link to publication]

Explaining variability in tacrolimus pharmacokinetics

Press R.R., Ploeger B.A., Hartigh J. d, Straaten T.v.d., Pelt J.v., Danhof M., Fijter J.W.d and Guchelaar H.J., Explaining variability in tacrolimus pharmacokinetics to optimize early exposure in adult kidney transplant recipients, Ther Drug Monit., 31(2): 187-197., 2009. [Link to publication]

Dose Prediction of Tacrolimus in de novo Kidney Transplant Patients with Population Pharmacokinetic Modelling Including Genetic Polymorphisms

Press R.R., Ploeger B.A., Hartigh J.d., Straaten R.J.H.M.v.d., Pelt J.v., Danhof M., Fijter J.W.d. and Guchelaar H.J., Dose Prediction of Tacrolimus in de novo Kidney Transplant Patients with Population Pharmacokinetic Modelling Including Genetic Polymorphisms. PAGE.(2007). [Link to publication]