Publications & Presentations in the therapeutic area :

A model-based approach to predict SC administration and free target dynamics for monoclonal antibodies using PK and total target measurements after IV administration.

Berkhout J., Fairman D., Noort van Noort, and Steeg van T.J. A model-based approach to predict SC administration and free target dynamics for monoclonal antibodies using PK and total target measurements after IV administration. PAGE 2024 [Link to publication]

Application of quantitative protein mass spectrometric data in the early predictive analysis of membrane-bound target engagement by monoclonal antibodies.

Sepp A., Muliaditan M. Application of quantitative protein mass spectrometric data in the early predictive analysis of membrane-bound target engagement by monoclonal antibodies. Mabs, 2024 [Link to publication].

Application of quantitative protein mass spectrometric data in the early predictive analysis of target engagement by monoclonal antibodies.

Muliaditan M, Sepp A. Application of quantitative protein mass spectrometric data in the early predictive analysis of target engagement by monoclonal antibodies. Clin Transl Sci. 2022. [Link to publication]

Linear pharmacokinetic parameters for monoclonal antibodies are similar within a species and across different pharmacological targets

Betts A., Keunecke A., Steeg T.J.v., Graaf P.H.v.d., Avery L.B., Jones H., Berkhout J. Linear pharmacokinetic parameters for monoclonal antibodies are similar within a species and across different pharmacological targets: A comparison between human, cynomolgus monkey and hFcRn Tg32 transgenic mouse using a population-modeling approach. MAbs: 1–55, 2018. [Link to publication]

Development of a mathematical model to elucidate the cross- linking of GSK1995057 and ADAs and binding to TNFR1 receptor

Steeg T.J.v., Keunecke A., Fairman D. Development of a mathematical model to elucidate the cross- linking of GSK1995057 and ADAs and binding to TNFR1 receptor – filling the gap between hypothesis and reality. PAGE, 2018. [Link to publication]

The application of mathematical modelling to the design of bispecific monoclonal antibodies

van Steeg T.J., Bergmann K.R., Dimasi N., Sachsenmeier K.F. and Agoram B., The application of mathematical modelling to the design of bispecific monoclonal antibodies, MAbs., 8(3): 585-592. doi: 510.1080/19420862.19422016.11141160. Epub 19422016 Feb 19420824., 2016. [Link to publication]

Does it take two or four to tango? Modeling & simulation of bispecific antibodies in oncology

Steeg T.v., Bergmann K., huang Q., Sachsenmeier K. and Agoram B., Does it take two or four to tango? Modeling & simulation of bispecific antibodies in oncology. Noordwijkerhout.(2014)

Application of M&S for Bispecifics in early discorvery.

Steeg T.v., Bergmann K., agoram B. and Sachsenmeier K., Application of M&S for Bispecifics in early discorvery. PKPK of novel constructs.(2013)

Development of a mechanistic based model for neonatal Fc receptor recycling to design human serum albumin mutants with extended half-lives

Bergmann K., Steeg T.v., Smeets J., Chaudhury C. and Agoram B., Development of a mechanistic based model for neonatal Fc receptor recycling to design human serum albumin mutants with extended half-lives PAGE.(2012) [Link to publication]

Expertise