Publications & Presentations in the therapeutic area :

Evaluation of the Long-Term Durability and Glycemic Control of Fasting Plasma Glucose and Glycosylated Hemoglobin

Stringer F., DeJongh J., Enya K., Koumura E., Danhof M. and Kaku K., Evaluation of the Long-Term Durability and Glycemic Control of Fasting Plasma Glucose and Glycosylated Hemoglobin for Pioglitazone in Japanese Patients with Type 2 Diabetes, Diabetes Technol Ther, 22: 22, 2014. [Link to publication]

A Semi-Mechanistic Modeling approach to support Phase III dose selection for TAK-875 Integrating Glucose and HbA1c Data

Stringer F., Matsuno K., Snelder N. and Hirayama M., A Semi-Mechanistic Modeling approach to support Phase III dose selection for TAK-875 Integrating Glucose and HbA1c Data in Japanese Type 2 Diabetes Patients. PAGE.(2013)  [Link to publication]

A population PK-PD model for effects of Sipoglitazar on FPG and HbA1c in patients with type II diabetes

Stringer F., DeJongh J., Scott G. and Danhof M., A population PK-PD model for effects of Sipoglitazar on FPG and HbA1c in patients with type II diabetes. PAGE.(2013) [Link to publication]

Evaluation of the Impact of UGT Polymorphism

Stringer F., Ploeger B.A., Jongh J.d., Scott G., Urquhart R., Karim A. and Danhof M., Evaluation of the Impact of UGT Polymorphism on the Pharmacokinetics and Pharmacodynamics of the Novel PPAR Agonist Sipoglitazar, J Clin Pharmacol., 53(3): 256-263, 2013. [Link to publication]

A model-based approach to analyze the influence of UGT2B15

Stringer F., Dejongh J., Scott G. and Danhof M., A model-based approach to analyze the influence of UGT2B15 polymorphism driven pharmacokinetic differences on the pharmacodynamic response of the PPAR agonist sipoglitazar, J Clin Pharmacol, 11(10): 227, 2013. [Link to publication]

Genotyped versus phenotyped dosing to account for UGT polymorphism of the novel PPAR agonist sipoglitazar

Stringer  F., Ploeger B., Jongh J.d., Scott G., Urquart R., Karim A. and Danhof M., Genotyped versus phenotyped dosing to account for UGT polymorphism of the novel PPAR agonist sipoglitazar PAGE.(2009). [Link to publication]

Long-term effects of pioglitazone, metformin and gliclazide

Winter W.d., Jongh J.d, Post T., Ploeger B., Urquhart R., Moules I., Eckland D. and Danhof M., A mechanism-based disease progression model for comparison of long-term effects of pioglitazone, metformin and gliclazide on disease processes underlying Type 2 Diabetes Mellitus, J Pharmacokinet Pharmacodyn., 33(3): 313-343., 2006. [Link to publication]

Treatment Efficacy of Combination-Therapy

Post T.M., Winter W.d., Jongh J.d., Moules I., Urquhart R., Eckland D. and Danhof M., Treatment Efficacy of Combination-Therapy based on a Mechanistic Characterisation of Disease Processes in Type 2 Diabetes Mellitus over a two-year period. PAGE.(2005). [Link to publication]

Robust fitting of pharmacokinetic models to Phase II/III clinical trial data

Freijer J., Greef I.d., Post T. and Ploeger B., Robust fitting of pharmacokinetic models to Phase II/III clinical trial data. PAGE.(2005). [Link to publication]

Mechanistic Disease Progression Analysis Indicates that Pioglitazone Improves ß-cell Function in Treatment-naïve Type 2 Diabetics

Winter W.d., Jongh J.d., Urquhart R., Moules I., Eckland D. and Danhof M., Mechanistic Disease Progression Analysis Indicates that Pioglitazone Improves ß-cell Function in Treatment-naïve Type 2 Diabetics. ADA.(2005).