Publications & Presentations in the therapeutic area :

User-friendly parameter identifiability methods with a workflow to guide model development, using categorical and continuous scales.

Noort van M., Ruppert M., DeJongh J., Marostica E., Bosch R., Mešic´ E., Snelder N. User-friendly parameter identifiability methods with a workflow to guide model development, using categorical and continuous scales. PAGE 2024 [Link to publication]

Case study of Exposure-Safety analysis in Phase 1 oncology – lessons learned.

Keunecke A., Goulooze S.C, Post T.M., Melhem M., Struemper H., Wang T. Case study of Exposure-Safety analysis in Phase 1 oncology – lessons learned. PAGE 2024 [Link to publication]

The drug titration paradox in the presence of intra-individual variation: can we estimate the true concentration-effect relationship?

Goulooze S.C., Krekels E.H.J., Noort van M., Knibbe C.A.J. The drug titration paradox in the presence of intra-individual variation: can we estimate the true concentration-effect relationship? PAGE 2024 [Link to publication]

Time-varying covariates, mediation analysis and overadjustment bias in PK/PD modelling.

Goulooze S.C, Snelder N. Time-varying covariates, mediation analysis and overadjustment bias in PK/PD modelling. PAGE 2024 [Link to publication]

Navigating the landscape of parameter identifiability methods: A workflow recommendation for model development.

Noort van M., Ruppert M., DeJongh J., Marostica E., Bosch R., Mešić E., Snelder N. Navigating the landscape of parameter identifiability methods: A workflow recommendation for model development. CPT: Pharmacometrics & Systems Pharmacology 2024 [Link to publication].

Two new user-friendly methods to assess pharmacometric parameter identifiability on categorical and continuous scales.

Noort van M., Ruppert M. Two new user-friendly methods to assess pharmacometric parameter identifiability on categorical and continuous scales. CPT: Pharmacometrics & Systems Pharmacology, 2024 [Link to publication].

Two New User-Friendly Approaches to Assess Pharmacometric Model Identifiability.

Noort van M., DeJongh J. Two New User-Friendly Approaches to Assess Pharmacometric Model Identifiability. PAGE 2023 [Link to publication]

Building an adaptive dose simulation framework to aid dose and schedule selection.

Richard Hooijmaijers R., Parasrampuria R., Marostica E., Ferron-Brady G., Post T.M., Visser S.A.G. Building an adaptive dose simulation framework to aid dose and schedule selection. CPT: Pharmacometirics & Systems Pharmacology, 2023. [Link to publication].

Performance of the SAEM and FOCEI algorithms in the open-source non-linear mixed effect modelling tool nlmixr

Schoemaker R., Fidler M., Laveille C., Wilkins J. J., Hooijmaijers R., Post T. M., Trame M. N., Xiong Y., Wang W. Performance of the SAEM and FOCEI algorithms in the open-source non-linear mixed effect modelling tool nlmixr. CPT pharmacometrics Syst. Pharmacol.: 2019. [Link to publication]