Presentations

User-friendly parameter identifiability methods with a workflow to guide model development, using categorical and continuous scales.

Noort van M., Ruppert M., DeJongh J., Marostica E., Bosch R., Mešic´ E., Snelder N. User-friendly parameter identifiability methods with a workflow to guide model development, using categorical and continuous scales. PAGE 2024 [Link to publication]

Population analysis of MG-ADL total score for efgartigimod Phase 3 study in myasthenia gravis patients: application of a bounded-integer model.

Marostica E., Ahsman M., Bragt van T., Noukens J., Vis P., T’joen C., Ulrichts P., Guglietta A., Rossenu S., Steeg van T. Population analysis of MG-ADL total score for efgartigimod Phase 3 study in myasthenia gravis patients: application of a bounded-integer model. PAGE 2024 [Link to publication]

A population PK analysis of docetaxel after IV administration of CPC634 (CriPec® docetaxel) and generic docetaxel in plasma and tumor.

Zeiser S., Rietveld P., Rijcken C., Snelder N. A population PK analysis of docetaxel after IV administration of CPC634 (CriPec® docetaxel) and generic docetaxel in plasma and tumor. PAGE 2024 [Link to publication]

The effect of pH on intratumoural docetaxel release from polymeric nanoparticle CPC634.

Rietveld P,  Koolen S L.W. , Zeiser S., Snelder N., Rijcken C.J. , Koch B.C.P., Mathijssen R.H.J. , Sassen S.D.T. The effect of pH on intratumoural docetaxel release from polymeric nanoparticle CPC634. PAGE 2024 [Link to publication]

From In Vitro Efficacy to Long-term HbA1c Response for GLP-1R/GlucagonR Agonism using the 4GI-HbA1c Systems Model.

Bosch R., Petrone M., Arends R., Sijbrands E.J.G., Hoefman S.,  Snelder N. From In Vitro Efficacy to Long-term HbA1c Response for GLP-1R/GlucagonR Agonism using the 4GI-HbA1c Systems Model. PAGE 2024 [Link to publication]

Case study of Exposure-Safety analysis in Phase 1 oncology – lessons learned.

Keunecke A., Goulooze S.C, Post T.M., Melhem M., Struemper H., Wang T. Case study of Exposure-Safety analysis in Phase 1 oncology – lessons learned. PAGE 2024 [Link to publication]

The drug titration paradox in the presence of intra-individual variation: can we estimate the true concentration-effect relationship?

Goulooze S.C., Krekels E.H.J., Noort van M., Knibbe C.A.J. The drug titration paradox in the presence of intra-individual variation: can we estimate the true concentration-effect relationship? PAGE 2024 [Link to publication]

Time-varying covariates, mediation analysis and overadjustment bias in PK/PD modelling.

Goulooze S.C, Snelder N. Time-varying covariates, mediation analysis and overadjustment bias in PK/PD modelling. PAGE 2024 [Link to publication]

Novel maturation function to capture the maturation of hepatic clearance in Preterm and Term Neonates to older infants, children and Adults: application to paracetamol and metabolites PK.

Wu Y.,  Völler S., Goulooze S.C.,  Allegaert K., Sherwin C.M. T., Rongen van A., Roofthooft  D.W.E., Simons S.H.P., Tibboel D., Flint R.B., Anker van den J.N.,  Knibbe C.A.J. Novel maturation function to capture the maturation of hepatic clearance in Preterm and Term Neonates to older infants, children and Adults: application to paracetamol and metabolites PK.…

Belimumab Pharmacokinetic Simulations to Select an Appropriate Subcutaneous Dosing Regimen to Treat Paediatric Patients with Active Lupus Nephritis.

Vendel E., Noort van N.,  Vis P., Liefaard L., Dimelow R. Belimumab Pharmacokinetic Simulations to Select an Appropriate Subcutaneous Dosing Regimen to Treat Paediatric Patients with Active Lupus Nephritis. PAGE 2024 [Link to publication]