- All
- Anesthesiology
- Anti-infectives and immunology
- Biologicals
- Blood disorders
- Cardiovascular
- CNS
- Diabetes
- Endocrinology/Sexual health
- Gastrointestinal Diseases
- General modelling
- Lung Diseases
- Methods
- Oncology
- Paediatrics
- Pain
- Peripheral Nervous System
- Safety pharmacology
Berg van der P., Post T., Ahsman M., Berg van der P., Hooijmaijers R., Snelder N., Yang S., ., Vasist L., Mahar K., Visser S. Population Dose-Response Analysis of Hemoglobin Data From Global Phase 2 and Japanese Phase 3 Studies With Daprodustat in Chronic Kidney Disease Patients With Anemia Following Once Daily (OD) or 3x Weekly (TIW) Administration. ASCPT 2021.
Mahar K., Post T., Ahsman M., Berg van der P., Hooijmaijers R., Snelder N., Vasist L., Visser S. Population Pharmacokinetic Analysis of Daprodustat in Healthy Volunteers (HV), Global Phase 2 and Japanese Phase 3 Studies in Chronic Kidney Disease Patients with Anemia Following Once Daily (QD) or 3x Weekly (TIW) Administration. ASCPT 2021.
Snelder N., Post T., Berg van der P., Hooijmaijers R., Ahsman M., Vasist L., Mahar K., Visser S. Population Pharamcokinetic/pharmacodynamics (PKPD) Analysis of EPO during daprodustat treatment in healthy volunteers (HV) and chronic kidney disease (CKD) patients with Anemia. ASCPT 2021.
Schoemaker R., Fidler M., Laveille C., Wilkins J.J., Hooijmaijers R., Post T.M., Trame M.N., Xiong Y., Wang W. Performance of the SAEM and FOCEI algorithms in the open-source non-linear mixed effect modelling tool nlmixr. PAGE, 2019. [Link to publication]
Grothey A., Hoefman S., Ruppert M., Vis P., Zisowsky J., Cutsem E., Dochy E.v. Fiala-buskies S., Cleton A., Ploeger B. Exploration of efficacious alternative regorafenib regimens to manage hand − foot skin reaction. ESMO, 2019.
Ploeger B., Hoefman S., Ruppert M., Vis P., Zisowsky J., Grothey A., Cutsem E., Dochy E.v., Cleton A. Exploration of alternative regorafenib regimens to manage hand – foot skin reaction. European Society for Medical Oncology 21st World Congress on Gastrointestinal Cancer, 2019. [Link to publication]
Berkhout J., Post T.M., Xu L., Zhang L., Wendland J., Faessel H., Vakilynejad M. Application of population PK/PD modeling and simulation to inform the design of a dose-finding study in patients with schizophrenia. PAGE, 2019. [Link to publication]
Dejongh J. Ahsman M.& Snelder N. A mechanism-based population K-PD model for long-term testosterone inhibition in prostate cancer patients under intermittent androgen deprivation therapy. PAGE 2019/ IATDMCTS 2019. [Link to publication]
Bosch R., Petrone M.,Hoefman S., Arends R., Vicini P., Snelder N. Integrate QSP model of in vivo human glucose regulation to support development of a glucagon/GLP-1 dual agonist. WCDT 2019. [Link to publication]
Berg P.v.d., Post T.M., Gao W., Miller R., Kesisoglou F., Arrington L., Rizk M.L.
Application of a MK-3682 minimal PBPK-PD model to explain discrepancy between enhanced efficacy and PK in the presence of itraconazole. ACoP9, 2018.
Hooijmaijers R., Fidler M., Schoemaker R., Trame M.N., Wang W., Wilkins J., Post T.M. ShinyMixR : A project-centric R / Shiny run management tool for nlmixr. PAGE, 2018. [Link to publication]
Berg P.v.d., Post T.M., Gao W., Miller R., Kesisoglou F., Arrington L., Rizk M.L. An HCV nucleoside inhibitor MK-3682 minimal PBPK-PD model for application in hypothesis generation regarding metabolic pathways and perturbations under various conditions. PAGE, 2018. [Link to publication]
Bosch R., Petrone M., Vicini P., Snelder N. A novel integrated QSP model of in vivo human glucose regulation to support development of a glucagon/GLP-1 dual agonist. PAGE, 2018. [Link to publication]
Jongh J. de. 35 years of modelling and simulation as robust tools in drug development From terminal half-life to quantitative and translational systems pharmacology. 22nd MDO / 33rd JSSX, 2018.
Steeg T.J.v., Keunecke A., Fairman D. Development of a mathematical model to elucidate the cross- linking of GSK1995057 and ADAs and binding to TNFR1 receptor – filling the gap between hypothesis and reality. PAGE, 2018. [Link to publication]