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Fidler M., Wilkins J.J., Hooijmaijers R., Post T.M., Schoemaker R,. Trame M.N., Xiong Y., Wang W.. Nonlinear mixed-effects model development and simulation using nlmixr and related R open source packages. CPT Pharmacometrics Syst Pharmacol: 621-633, 2019. [Link to publication]
Snelder N., Drenth H.J., Riber Bergmann K., Wood N.D., Hibberd M., Scott G. Population pharmacokinetic – pharmacodynamic modelling of the relationship between testosterone and prostate specific antigen in patients with prostate cancer during treatment with leuprorelin. Br J Clin Pharmacol: 1–13, 2019. [Link to publication]
Shah A., Solms A., Wiegmann S., Ahsman M., Berntorp E., Tiede A., Iorio A., Mancuso M.E., Zhivkov T., Lissitchkov T. Direct comparison of two extended-half-life recombinant FVIII products: a randomized, crossover pharmacokinetic study in patients with severe hemophilia A. Annals of Hematology: 2035-2044, 2019. [Link to publication]
Schoemaker R., Fidler M., Laveille C., Wilkins J. J., Hooijmaijers R., Post T. M., Trame M. N., Xiong Y., Wang W. Performance of the SAEM and FOCEI algorithms in the open-source non-linear mixed effect modelling tool nlmixr. CPT pharmacometrics Syst. Pharmacol.: 2019. [Link to publication]
Berends S.E., Steeg T.J.v., Ahsman M.J., Singh S,. Brandse J.F., D’Haens G.R.A.M., Mathôt R.A.A. Tumor necrosis factor-mediated disposition of infliximab in ulcerative colitis patients. J. Pharmacokinet. Pharmacodyn.: 5, 2019. [Link to publication]
Solms A., Iorio A., Ahsman M. J., Vis P., Shah A., Berntorp E., Garmann D. Favorable Pharmacokinetic Characteristics of Extended ‑ Half ‑ Life Recombinant Factor VIII BAY 94 ‑ 9027 Enable Robust Individual Profiling Using a Population Pharmacokinetic Approach. Clin. Pharmacokinet, 2019. [Link to publication]
Snelder N., Heinig R., Drenth H.J., Joseph A., Kolkhof P., Lippert J., Garmann D., Ploeger B., Eissing T. Population Pharmacokinetic and Exposure–Response Analysis of Finerenone: Insights Based on Phase IIb Data and Simulations to Support Dose Selection for Pivotal Trials in Type 2 Diabetes with Chronic Kidney Disease. Clin. Pharmacokinet: 1179-1926, 2019. [Link to publication]
Bosch R., Petrone M., Hoefman S., Arends R., Vicini P., Snelder N. Predicting the effect of GLP-1 agonists on glucose and HbA1c with a 4GI-HbA1c modelo. ACOP, 2019. [Link to publication]
Reinecke I., Hofmann B., Mesic E., Drenth H.J., Garmann D. An integrated population pharmacokinetic analysis to characterize levonorgestrel pharmacokinetics after different administration routes. J Clin Pharmacol: 1639-1654, 2018. [Link to publication]
Betts A., Keunecke A., Steeg T.J.v., Graaf P.H.v.d., Avery L.B., Jones H., Berkhout J. Linear pharmacokinetic parameters for monoclonal antibodies are similar within a species and across different pharmacological targets: A comparison between human, cynomolgus monkey and hFcRn Tg32 transgenic mouse using a population-modeling approach. MAbs: 1–55, 2018. [Link to publication]
Trame M.N., Riggs M., Biliouris K., Marathe D., Mettetal J., Post T.M., Rizk M.L., Visser S.A.G., Musante C.J. A Perspective on the State of Pharmacometrics and Systems Pharmacology Integration. CPT Pharmacometrics Syst Pharmacol: 617-620, 2018. [Link to publication]
Maanen E.M.T.v., Steeg T.J.v., Ahsman M., Michener M.S., Savage M.J., Kennedy M.E., Kleijn H.J., Stone J., Danhof M. Extending a systems model of the APP pathway: Separation of β- and γ-secretase sequential cleavage steps of APP. J. Pharmacol. Exp. Ther.: 507-518, 2018. [Link to publication]
Facius A., Marostica E., Gardiner P., Watz H., Lahu G. Pharmacokinetic and Pharmacodynamic Modelling to Characterize the Tolerability of Alternative Up-Titration Regimens of Roflumilast in Patients with Chronic Obstructive Pulmonary Disease. Clin. Pharmacokinet: 1029-1038, 2018. [Link to publication]
Schulthess P., Post T.M., Yates J., Graaf P.H.v.d. Frequency-Domain Response Analysis for Quantitative Systems Pharmacology Models. CPT Pharmacometrics Syst Pharmacol: 111–123, 2018. [Link to publication]
Goto, A., Tagawa, Y., Moriya, Y., Sato, S., Yamamoto, M., Wakabayashi T., Tsukamoto T., Jongh J.d., Steeg T.J.v., Moriwaki T., Asahi, S. Influence of Body Composition on Disposition of the Highly Fat Distributed Compound as Analyzed by Physiologically-based Pharmacokinetic (PBPK) Modeling and Simulation. Biopharmaceutics & Drug Disposition: 543-552, 2017. [Link to publication]