Population pharmacokinetic and pharmacodynamic modeling of propofol for long-term sedation in critically ill patients

Therapeutic area :

Knibbe C.A., Zuideveld K.P., Jongh J.d., Kuks P.F., Aarts L.P. and Danhof M. , Population pharmacokinetic and pharmacodynamic modeling of propofol for long-term sedation in critically ill patients: a comparison between propofol 6% and propofol 1%, Clin Pharmacol Ther. , 72 : 670-84., 2002. [Link to publication]