Publications & Presentations in the therapeutic area :

A cross-species translational pharmacokinetic-pharmacodynamic evaluation of core body temperature reduction by the TRPM8 blocker PF-05105679

Gosset J.R., Beaumont K., Matsuura T., Winchester W., Attkins N., Glatt S.,Lightbown I., Ulrich K., Roberts S., Harris J., Mesic E., Steeg T.J.v., Hijdra D., Graaf P.H.v.d.  A cross-species translational pharmacokinetic-pharmacodynamic evaluation of core body temperature reduction by the TRPM8 blocker PF-05105679. European Journal of Pharmaceutical Sciences: S161-S167 2017. [Link to publication]

Population Pharmacokinetic Modeling of Tapentadol Extended Release

Huntjens D.R., Liefaard L.C., Nandy P., Drenth H.J. and Vermeulen A., Population Pharmacokinetic Modeling of Tapentadol Extended Release (ER) in Healthy Subjects and Patients with Moderate or Severe Chronic Pain, Clin Drug Investig., 36(3): 213-223. doi: 210.1007/s40261-40015-40371-x., 2016. [Link to publication]

Static allodynia response to pregabalin and sildenafil

Bender G., Florian J.A., Jr., Bramwell S., Field M.J., Tan K.K., Marshall S., Jongh J.d, Bies R.R. and Danhof M., Pharmacokinetic-pharmacodynamic analysis of the static allodynia response to pregabalin and sildenafil in a rat model of neuropathic pain, J Pharmacol Exp Ther., 334(2): 599-608. Epub 2010 May 2015., 2010. [Link to publication]

Morphine glucuronidation

Knibbe C.A., Krekels E.H., Anker J.N.v.d., Jongh J.d., Santen G.W., Dijk M.v., Simons S.H., Lingen R.A.v., Jacqz-Aigrain E.M., Danhof M. and Tibboel D., Morphine glucuronidation in preterm neonates, infants and children younger than 3 years, Clin Pharmacokinet, 48(6): 371-385, 2009. [Link to publication]

Pharmacokinetic/pharmacodynamic modelling of the EEG effects of opioids

Groenendaal D., Freijer J., Rosier A., Mik D.d., Nicholls G., Hersey A., Ayrton A.D., Danhof M. and Lange E.C.d., Pharmacokinetic/pharmacodynamic modelling of the EEG effects of opioids: the role of complex biophase distribution kinetics, Eur J Pharm Sci., 34(2-3): 149-163. Epub 2008 Mar 2030., 2008. [Link to publication]

Disease Severity Is a Major Determinant for the Pharmacodynamics of Propofol in Critically Ill Patients

Peeters M.Y., Bras L.J., Jongh J.d., Wesselink R.M., Aarts L.P., Danhof M. and Knibbe C.A., Disease Severity Is a Major Determinant for the Pharmacodynamics of Propofol in Critically Ill Patients, Clin Pharmacol Ther, 8: 8, 2007. [Link to publication]

Population pharmacokinetic modelling of non-linear brain distribution of morphine

Groenendaal D., Freijer J., Mik D.d., Bouw M.R., Danhof M. and Lange E.C.d., Population pharmacokinetic modelling of non-linear brain distribution of morphine: influence of active saturable influx and P-glycoprotein mediated efflux, Br J Pharmacol., 151(5): 701-712. Epub 2007 Apr 2030., 2007. [Link to publication]

Influence of biophase distribution and P-glycoprotein interaction

Groenendaal D., Freijer J., Mik D.d., Bouw M.R., Danhof M. and Lange E.C.d., Influence of biophase distribution and P-glycoprotein interaction on pharmacokinetic-pharmacodynamic modelling of the effects of morphine on the EEG, Br J Pharmacol., 151(5): 713-720. Epub 2007 Apr 2030., 2007. [Link to publication]

Propofol pharmacokinetics and pharmacodynamics for depth of sedation

Peeters M.Y., Prins S.A., Knibbe C.A., Jongh J.d., Schaik R.H.v., Dijk M.v., Heiden I.P.v.d., Tibboel D. and Danhof M., Propofol pharmacokinetics and pharmacodynamics for depth of sedation in nonventilated infants after major craniofacial surgery, Anesthesiology, 104(3): 466-474, 2006. [Link to publication]

Pharmacokinetics and pharmacodynamics of midazolam and metabolites

Peeters M.Y., Prins S.A., Knibbe C.A., Jongh J.d., Mathot R.A., Warris C., Schaik R.H.v., Tibboel D. and Danhof M., Pharmacokinetics and pharmacodynamics of midazolam and metabolites in nonventilated infants after craniofacial surgery, Anesthesiology., 105(6): 1135-1146., 2006. [Link to publication]