Pharmacokinetic/pharmacodynamic modelling of the EEG effects of opioids

Therapeutic area :

Groenendaal D., Freijer J., Rosier A., Mik D.d., Nicholls G., Hersey A., Ayrton A.D., Danhof M. and Lange E.C.d., Pharmacokinetic/pharmacodynamic modelling of the EEG effects of opioids: the role of complex biophase distribution kinetics, Eur J Pharm Sci., 34(2-3): 149-163. Epub 2008 Mar 2030., 2008. [Link to publication]