Publications & Presentations in the therapeutic area :

Neuroprotection after cardiac arrest with 2-iminobiotin

Admiraal M.M., Velseboer D.C., Tjabbes H., Vis P., Peeters-Scholte C., Horn J. Neuroprotection after cardiac arrest with 2-iminobiotin: a single center phase IIa study on safety, tolerability, and pharmacokinetics. Frontiers in Neurology 2023. [Link to publication ].

Application of population PK/PD modeling and simulation to inform the design of a dose-finding study in patients with schizophrenia

Berkhout J., Post T.M., Xu L., Zhang L., Wendland J., Faessel H., Vakilynejad M. Application of population PK/PD modeling and simulation to inform the design of a dose-finding study in patients with schizophrenia. PAGE, 2019.  [Link to publication]

Extending a systems model of the APP pathway

Maanen E.M.T.v., Steeg T.J.v., Ahsman M., Michener M.S., Savage M.J., Kennedy M.E., Kleijn H.J., Stone J., Danhof M. Extending a systems model of the APP pathway: Separation of β- and γ-secretase sequential cleavage steps of APP. J. Pharmacol. Exp. Ther.: 507-518, 2018. [Link to publication]

Systems pharmacology analysis of the Aβ oligomer response following β-secretase inhibition

Maanen E.M.T.v., Steeg T.J.v., Kalinina J., Michener M.S., Savage M.J., Kennedy M.E., Parker E.M., Danhof M. Systems pharmacology analysis of the Aβ oligomer response following β-secretase inhibition: Evidence for second-order kinetics of Aβ42 oligomerization. AAIC, 2017.

A systems pharmacology approach unfolds Aβ oligomer modulation

Maanen E.M.T.v., Steeg T.J.v., Kalinina J., Michener M.S., Savage, M.J., Kennedy M.E., Parker E.M., Danhof, M. A systems pharmacology approach unfolds Aβ oligomer modulation and unravels the dynamics of the APP pathway. Page 2017. [Link to publication]

Resilience in the Amyloid Precursor Protein ( APP ) pathway revealed

Maanen E.M.T., Steeg, TJ.v., Kalinina J., Stone, J., Michener M.S., Savage M.J., Parker E.M., Danhof, M. Resilience in the Amyloid Precursor Protein ( APP ) pathway revealed by systems pharmacology modeling following β – and γ -secretase inhibition. AAIC, 2017.

Quantification of the modulation of the Aβ oligomers following secretase inhibition

Maanen E.v., Steeg T.v., Savage M.J., Michener M.S., Stone J. and Danhof M., Quantification of the modulation of the Aβ oligomers following secretase inhibition; A systems pharmacology approach. Computational Hub Meeting.(2016)

Quantification of the modulation of Aβ oligomers following secretase inhibition- A systems pharmacology approach

Maanen E.v., Steeg T.v., Kalinina J., Stone J., Michener M.S., Savage M.J., Parker E.M. and Danhof M. (2016). Quantification of the modulation of Aβ oligomers following secretase inhibition- A systems pharmacology approach. ACOP (2016)

Systems Pharmacology Analysis of the Amyloid Cascade

van Maanen, E.M., et al., Systems Pharmacology Analysis of the Amyloid Cascade after beta-Secretase Inhibition Enables the Identification of an Abeta42 Oligomer Pool. J Pharmacol Exp Ther., 2016. 357(1): p. 205-16. doi: 10.1124/jpet.115.230565. Epub 2016 Jan 29. [Link to publication]

A systems pharmacology model accounting for tracer dynamics throughout the APP pathway

Maanen E.v., Steeg T.v., Stone J., Dobrowolska J., Michener M., Savage M., Kennedy M., Bateman R., Kleijn H. and Danhof M., A systems pharmacology model accounting for tracer dynamics throughout the APP pathway: Implications for interpretation of BACE inhibition response in CMP rhesus monkeys. Noordwijkerhout.(2014)