Publications & Presentations in the therapeutic area :

Population pharmacodynamic modelling of lorazepam- and midazolam-induced sedation upon long-term continuous infusion in critically ill patients

Swart E.L., Zuideveld K.P., Jongh J.d., Danhof M., Thijs L.G.  and Strack van Schijndel R.M., Population pharmacodynamic modelling of lorazepam- and midazolam-induced sedation upon long-term continuous infusion in critically ill patients, Eur J Clin Pharmacol., 62(3): 185-194., 2006. [Link to publication]

Population pharmacokinetics of lorazepam and midazolam and their metabolites in intensive care patients

Swart E.L., Jongh J.d., Zuideveld K.P., Danhof M., Thijs L.G. and Strack van Schijndel R.J., Population pharmacokinetics of lorazepam and midazolam and their metabolites in intensive care patients on continuous venovenous hemofiltration, Am J Kidney Dis., 45(2): 360-371., 2005. [Link to publication]

Reversal of rocuronium-induced neuromuscular block by cyclodextin ORG 25969

Ploeger B., Houwing N., Bom A., Zollinger D. and Danhof M., Reversal of rocuronium-induced neuromuscular block by cyclodextin ORG 25969: model development and validation. PAGE.(2004). [Link to publication]

PK-PD modelling of reversal of neuromuscular by a chemically optimised cyclodextrin

Ploeger B., Ruigt G.S., Bom A., Houwing N., Iersel M.P.v. and Danhof M., PK-PD modelling of reversal of neuromuscular by a chemically optimised cyclodextrin. ASCPT.(2004).

Comparative population pharmacokinetics of lorazepam and midazolam during long-term continuous infusion in critically ill patients

Swart E.L., Zuideveld K.P., Jongh J.d., Danhof M., Thijs L.G. and Strack van Schijndel R.M., Comparative population pharmacokinetics of lorazepam and midazolam during long-term continuous infusion in critically ill patients, Br J Clin Pharmacol., 57(2): 135-145., 2004. [Link to publication]

Population pharmacokinetic modeling of blood-brain barrier transport of synthetic adenosine A1 receptor agonists

Schaddelee M.P., Groenendaal D., Jongh J.d., Cleypool C.G., AP I.J., Boer A.G. d. and Danhof M., Population pharmacokinetic modeling of blood-brain barrier transport of synthetic adenosine A1 receptor agonists, J Pharmacol Exp Ther, 311(3): 1138-1146, 2004. [Link to publication]

Population pharmacokinetic-pharmacodynamic modelling of the anti-hyperalgesic effect of 5’deoxy-N6-cylopentyladenosine

Schaddelee M.P., Jongh J.d., Collins S.D., Boer A.G.d., Ijzerman A.P. and Danhof M., Population pharmacokinetic-pharmacodynamic modelling of the anti-hyperalgesic effect of 5’deoxy-N6-cylopentyladenosine in the mononeuropathic rat, Eur J Pharmacol, 504(1-2): 7-15, 2004. [Link to publication]