Publications & Presentations in the therapeutic area :

Performance of the SAEM and FOCEI algorithms in the open-source non-linear mixed effect modelling tool nlmixr

Schoemaker R., Fidler M., Laveille C., Wilkins J.J., Hooijmaijers R., Post T.M., Trame M.N., Xiong Y., Wang W. Performance of the SAEM and FOCEI algorithms in the open-source non-linear mixed effect modelling tool nlmixr. PAGE, 2019. [Link to publication]

Nonlinear mixed-effects model development and simulation using nlmixr and related R open source packages

Fidler M., Wilkins J.J., Hooijmaijers R., Post T.M., Schoemaker R,. Trame M.N., Xiong Y., Wang W.. Nonlinear mixed-effects model development and simulation using nlmixr and related R open source packages. CPT Pharmacometrics Syst Pharmacol: 621-633, 2019. [Link to publication] 

A Perspective on the State of Pharmacometrics and Systems Pharmacology Integration

Trame M.N., Riggs M., Biliouris K., Marathe D., Mettetal J., Post T.M., Rizk M.L., Visser S.A.G., Musante C.J. A Perspective on the State of Pharmacometrics and Systems Pharmacology Integration. CPT Pharmacometrics Syst Pharmacol: 617-620, 2018. [Link to publication] 

A project-centric R / Shiny run management tool for nlmixr

Hooijmaijers R., Fidler M., Schoemaker R., Trame M.N., Wang W., Wilkins J., Post T.M. ShinyMixR : A project-centric R / Shiny run management tool for nlmixr. PAGE, 2018. [Link to publication]

35 years of modelling and simulation

Jongh J. de. 35 years of modelling and simulation as robust tools in drug development From terminal half-life to quantitative and translational systems pharmacology. 22nd MDO / 33rd JSSX, 2018.

A Perspective on integrating Pharmacometrics and Quantitative Systems Pharmacology characteristics

Trame M.N., Post T.M. Session 1c:  A Perspective on integrating Pharmacometrics and Quantitative Systems Pharmacology characteristics using examples. ACoP9, 2018.  [Link to publication]

Application of an iPSP Model

Post T.M. Application of an iPSP Model with Reduced Mechanistic Detail for a Disease System Analysis applied to Osteoporosis. ACoP9, 2018. [Link to publication]

Tutorial 1: nlmixr: Population Modeling in R

Fidler M., Wang W., Post T.M., Wilkins J., Schoemaker R., Trame M.N. Tutorial 1:  nlmixr: Population Modeling in R. ACoP9, 2018. [Link to publication]

Solving sensitivity equations by inductive linearization and its applications in population pharmacokinetic and pharmacodynamic models via FOCEi

Fidler M, Xiong Y, Schoemaker R, Wilkins J, Trame M.N, Post T.M, Hooijmaijers R, Wang W., Solving sensitivity equations by inductive linearization and its applications in population pharmacokinetic and pharmacodynamic models via FOCEi. ACoP9 2018

Exploring inductive linearization in population pharmacokinetic and pharmacodynamic models

Fidler M, Xiong Y, Schoemaker R, Wilkins J, Trame M.N, Post T.M, Hooijmaijers R, Wang W. Exploring inductive linearization in population pharmacokinetic and pharmacodynamic models. ACoP9, 2018.