Publications & Presentations in the therapeutic area :

Clinical impact of genetic polymorphisms observed in the pharmacokinetics of the novel PPAR agonist, Sipoglitazar

Stringer F., Jongh J.d, Ploeger B., Scott G., Urquart R. and Danhof M., Clinical impact of genetic polymorphisms observed in the pharmacokinetics of the novel PPAR agonist, Sipoglitazar. Noordwijkerhout.(2010)

Clinical Trial Simulation

Holford N., Ma S.C.and Ploeger B.A. Clinical Trial Simulation: A Review, Clin Pharmacol Ther. 7:7, 2010. [Link to publication]

Pharmacokinetics of clindamycin in pregnant women

Muller A.E., Mouton J.W., Oostvogel P.M., Dorr P.J., Voskuyl R.A., Jongh J.d., Steegers E.A. and Danhof M., The pharmacokinetics of clindamycin in pregnant women in the peripartum period, Antimicrob Agents Chemother, 2010. [Link to publication]

Towards the implementation of the Markov property into a continuous-time transition state model in NONMEM

Snelder N., Diack C., Benson N., Ploeger B.and Graaf P.v.d., Towards the implementation of the Markov property into a continuous-time transition state model in NONMEM. PAGE.(2009). [Link to publication]

Modelling non-linear dose-dependent absorption profiles after oral prolonged release formulations

Liefaard  L., Huntjens D., Vermeulen A. and Drenth H., Modelling non-linear dose-dependent absorption profiles after oral prolonged release formulations. PAGE.(2009).[Link to publication]

Population pharmacokinetic model of the pregabalin-sildenafil interaction in rats

Bender G., Gosset J., Florian J., Tan K., Field M., Marshall S., Jongh J.d., Bies R. and Danhof M., Population pharmacokinetic model of the pregabalin-sildenafil interaction in rats: application of simulation to preclinical PK-PD study design, Pharm Res, 26(10): 2259-2269, 2009. [Link to publication]

Incorporating receptor theory

Ploeger B.A., Graaf P.H.v.d and Danhof M., Incorporating receptor theory in mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling, Drug Metab Pharmacokinet., 24(1): 3-15., 2009. [Link to publication]

Implementing receptor theory in PK-PD modeling

Danhof M. and Ploeger B., Implementing receptor theory in PK-PD modeling. PAGE.(2008). [Link to publication]

Assessment of the use of complex baseline models in preclinical safety screening

Steeg T. v., Strougo A., Ploeger B. and Graaf P. v. d., Assessment of the use of complex baseline models in preclinical safety screening: Application of the van der Pol oscillator model to describe heart rate effects in rats. PAGE.(2008). [Link to publication]

Pharmacokinetic-pharmacodynamic modelling of fluvoxamine 5-HT transporter occupancy in rat frontal cortex

Geldof M., Freijer J.I., Beijsterveldt L.v., Langlois X. and Danhof M., Pharmacokinetic-pharmacodynamic modelling of fluvoxamine 5-HT transporter occupancy in rat frontal cortex, Br J Pharmacol., 154(6): 1369-1378. Epub 2008 May 1319., 2008.  [Link to publication]