Publications & Presentations in the therapeutic area :

Mechanism-based pharmacokinetic-pharmacodynamic modeling

Danhof M., Jongh J.d., Lange E.C.d., Della Pasqua O., Ploeger B.A.  and Voskuyl R.A., Mechanism-based pharmacokinetic-pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems analysis, Annu Rev Pharmacol Toxicol., 47: 357-400., 2007. [Link to publication]

Population pharmacokinetic model of fluvoxamine in rats

Geldof M., Freijer J., Beijsterveldt L.v., Timmerman P., Ahnaou A., Drinkenburg W.H. and Danhof M., Population pharmacokinetic model of fluvoxamine in rats: utility for application in animal behavioral studies, Eur J Pharm Sci., 30(1): 45-55. Epub 2006 Oct 2012., 2007. [Link to publication]

Pharmacokinetic-pharmacodynamic modeling of the effect of fluvoxamine on p-chloroamphetamine-induced behavior

Geldof M., Freijer J., Beijsterveldt L.v., Vermote P.C., Megens A.A. and Danhof M., Pharmacokinetic-pharmacodynamic modeling of the effect of fluvoxamine on p-chloroamphetamine-induced behavior, Eur J Pharm Sci., 32(3): 200-208. Epub 2007 Jul 2028., 2007. [Link to publication]

Accurate Interpretation of the Visual Predictive Check in order to Evaluate Model Performance

Post T.M., Freijer J.I., Winter W.d., Danhof M. and Ploeger B., Accurate Interpretation of the Visual Predictive Check in order to Evaluate Model Performance. PAGE.(2006). [Link to publication]

Disease system analysis distinguishing disease status from disease process

Jongh J.d., Post T., Freijer J., Winter W.d., Danhof M. and Ploeger B., Disease system analysis distinguishing disease status from disease process. Noordwijkerhout.(2006).

Basic disease progression models in degenerative disease

Post T.M., Freijer J.I., Jongh J.d. and Danhof M., Disease system analysis: basic disease progression models in degenerative disease, Pharm Res, 22(7): 1038-1049., 2005. [Link to publication]

Population pharmacokinetic analysis for simultaneous determination of B (max) and K (D) in vivo

Liefaard L.C., Ploeger B.A., Molthoff C.F., Boellaard R., Lammertsma A.A., Danhof M. and Voskuyl R.A., Population pharmacokinetic analysis for simultaneous determination of B (max) and K (D) in vivo by positron emission tomography, Mol Imaging Biol., 7(6): 411-421., 2005. [Link to publication]

Absorption model based on transport physics theory applied to Paracetamol

Freijer J.I., Post T.M., Ploeger B.A., Jongh J.d. and Danhof M., Absorption model based on transport physics theory applied to Paracetamol. ASCPT.(2004).

Application of Population Pharmacokinetic Analysis for Quantification of in vivo Binding Properties in the Rat Brain

Liefaard C.L., Ploeger B.A., Molthoff C.F.M., Boellaard R., Lammertsma A.A., Danhof M. and Voskuyl R.A., Application of Population Pharmacokinetic Analysis for Quantification of in vivo Binding Properties in the Rat Brain by Positron Emission Tomography. PAGE.(2004). [Link to publication]

Modelling of drug absorption as a transport proces limited

Freijer J.I., Post T.M., Ploeger B., Jongh J.d. and Danhof M., Modelling of drug absorption as a transport proces limited. PAGE.(2003). [Link to publication]