Publications & Presentations in the therapeutic area :

Assessment of the Potential for Displacement Interactions with Sugammadex

Zwiers A., Heuvel M.v.d., Smeets J. and Rutherford S., Assessment of the Potential for Displacement Interactions with Sugammadex: A Pharmacokinetic-Pharmacodynamic Modelling Approach, Clin Drug Investig, 10(10): 11584730-000000000, 2010. [Link to publication]

Reversal of neuromuscular blockade

Ploeger B.A., Smeets J., Strougo A., Drenth H.J., Ruigt G., Houwing N.  and Danhof M., Pharmacokinetic-pharmacodynamic model for the reversal of neuromuscular blockade by sugammadex, Anesthesiology., 110(1): 95-105., 2009. [Link to publication]

A Mechanism-based Pharmacokinetic Model Describing the Interaction Between Sugammadex and Rocuronium in Patients with Normal and Impaired Renal Function

Smeets J., Ploeger B., Strougo A., Liefaard L. and Kerbusch T., A Mechanism-based Pharmacokinetic Model Describing the Interaction Between Sugammadex and Rocuronium in Patients with Normal and Impaired Renal Function. PAGE.(2008). [Link to publication]

Development of a mechanism-based PK-PD model of the reversal of rocuronium-induced neuromuscular block by ORG25969

Ruigt G.S., Ploeger B., Danhof M., Bom A., Houwing N. and Iersel M.P.v., Development of a mechanism-based PK-PD model of the reversal of rocuronium-induced neuromuscular block by ORG25969. IARS.(2004). [Link to publication]