Publications & Presentations in the therapeutic area :

Advances in pharmacokinetic-pharmacodynamic modelling for pediatric drug development

Goulooze S.C, Vis P., Krekels E.H.J., Knibbe C.A.J. Advances in pharmacokinetic-pharmacodynamic modelling for pediatric drug development: extrapolations and exposure-response analyses. Expert Review of Clinical Pharmacology 2023 [Link to publication].

The Effect of Ibuprofen Exposure and Patient Characteristics on the Closure of the Patent Ductus Arteriosus in Preterm Infants.

Engbers A.G.J., Völler S., Flint R.B., Goulooze S.C., de Klerk J., Krekels E.H.J., van Dijk M., Willemsen S.P., Reiss I.K.M., Knibbe C.A.J., Simons S.H.P. The Effect of Ibuprofen Exposure and Patient Characteristics on the Closure of the Patent Ductus Arteriosus in Preterm Infants. Clin Pharmacol Ther. 2022 [Link to publication]

A Phase IIa Clinical Trial of 2 ‑ Iminobiotin for the Treatment of Birth Asphyxia in DR Congo

Biselele T., Bambi J., Betukumesu D. M., Ndiyo Y., Tabu G., Kapinga J., Bola V, Makaya P., Tjabbes H., Vis P., Peeters-Scholte C.. A Phase IIa Clinical Trial of 2 ‑ Iminobiotin for the Treatment of Birth Asphyxia in DR Congo , a Low ‑ Income Country. Pediatr. Drugs: 2020. [Link to publication]

Pharmacokinetics and short-term safety of the selective NOS inhibitor 2-iminobiotin in asphyxiated neonates treated with therapeutic hypothermia.

Favie L. M. A., Peeters-Scholte C. M. P. C. D., Bakker A., Tjabbes H., Egberts T. C. G., van Bel F., Rademaker C. M. A., Vis P., Groenendaal F. Pharmacokinetics and short-term safety of the selective NOS inhibitor 2-iminobiotin in asphyxiated neonates treated with therapeutic hypothermia. Pediatr. Res.: 2019. [Link to publication]

Model-Based Once-Daily Darunavir/Ritonavir Dosing Recommendations

Brochot A., Kakuda T.N., Van De Casteele T., Opsomer M., Tomaka F.L., Vermeulen A. and Vis P., Model-Based Once-Daily Darunavir/Ritonavir Dosing Recommendations in Pediatric HIV-1-Infected Patients Aged >/=3 to <12 Years, CPT Pharmacometrics Syst Pharmacol., 4(7): 406-414. doi: 410.1002/psp1004.1044. Epub 2015 Jun 1019., 2015. [Link to publication]

Morphine and its metabolites

Krekels E.H., Jongh J.d., Lingen R.A.v., Marel C.D.v.d., Choonara I., Lynn A.M., Danhof M., Tibboel D. and Knibbe C.A., Predictive performance of a recently developed population pharmacokinetic model for morphine and its metabolites in new datasets of (preterm) neonates, infants and children, Clin Pharmacokinet., 50(1): 51-63, 2011. [Link to publication]

Pharmacokinetics of penicillin G in infants

Muller A.E., Jongh J.d., Bult Y., Goessens W.H., Mouton J.W., Danhof M.  and Anker J.N.v.d., Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks, Antimicrob Agents Chemother, 23: 23, 2007. [Link to publication]