Stevens J., Ploeger B.A., Hammarlund-Udenaes M., Osswald G., van der Graaf P.H., Danhof M. and de Lange E.C., Mechanism-based PK-PD model for the prolactin biological system response following an acute dopamine inhibition challenge: quantitative extrapolation to humans, J Pharmacokinet Pharmacodyn., 39(5): 463-477. doi: 410.1007/s10928-10012-19262-10924. Epub 12012 Jul 10912., 2012. [Link to publication]
Westerhout J., Ploeger B., Smeets J., Danhof M. and de Lange E.C., Physiologically based pharmacokinetic modeling to investigate regional brain distribution kinetics in rats, Aaps J., 14(3): 543-553. doi: 510.1208/s12248-12012-19366-12241. Epub 12012 May 12217., 2012. [Link to publication]
Ravenstijn P.G., Drenth H.J., O’Neill M.J., Danhof M. and de Lange E.C., Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson’s disease, Fluids Barriers CNS., 9:4.(doi): 10.1186/2045-8118-1189-1184., 2012. [Link to publication]
Maanen E.V., Challenges in Non-Clinical Assessment of Antisense Oligonucleotides: Modelling Perspectives. AAPS (National Biotechnology Conference).(2011)
Diack C., Ackaert O., Ploeger B.A., Graaf P.H.v.d., Gurrell R., Ivarsson M. and Fairman D., A hidden Markov model to assess drug-induced sleep fragmentation in the telemetered rat, J Pharmacokinet Pharmacodyn, 10: 10, 2011. [Link to publication]
Diack C., Ackaert O., Ploeger B., Graaf P.v.d., Gurrell R., Ivarsson M. and Fairman D., A true Markov model for sleep disturbance. PAGE.(2010). [Link to publication]
Benson N., Snelder N., Ploeger B., Napier C., Sale H., Birdsall N.J., Butt R.P. and Graaf P.H.v.d., Estimation of binding rate constants using a simultaneous mixed-effects method: application to monoamine transporter reuptake inhibitor reboxetine, Br J Pharmacol., 160(2): 389-398., 2010. [Link to publication]
Ploeger B.A. and Holford N.H., Washout and delayed start designs for identifying disease modifying effects in slowly progressive diseases using disease progression analysis, Pharm Stat., 8(3): 225-238., 2009. [Link to publication]
Liefaard L.C., Ploeger B.A., Molthoff C.F., Jong H.W.d, Dijkstra J., Weerd L.v.d., Lammertsma A.A., Danhof M. and Voskuyl R.A., Changes in GABAA receptor properties in amygdala kindled animals: in vivo studies using [11C]flumazenil and positron emission tomography, Epilepsia., 50(1): 88-98., 2009. [Link to publication]
Ploeger B. and Holford N.H., Are Wash-Out Designs Better than Delayed Start Designs? ACOP.(2008).
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