Steeg T.J.v., Krekels E.H., Freijer J., Danhof M. and Lange E.C.d., Effect of altered AGP plasma binding on heart rate changes by S(-)-propranolol in rats using mechanism-based estimations of in vivo receptor affinity (K(B,vivo)), J Pharm Sci, 17: 17, 2009. [Link to publication]
Steeg T.J.v., Boralli V.B., Krekels E.H., Slijkerman P., Freijer J., Danhof M. and Lange E.C.d., Influence of plasma protein binding on pharmacodynamics: Estimation of in vivo receptor affinities of beta blockers using a new mechanism-based PK-PD modelling approach, J Pharm Sci., 98(10): 3816-3828., 2009. [Link to publication]
Steeg T.J.v., Freijer J., Danhof M. and Lange E. C. d., Mechanism-based pharmacodynamic modeling of S(-)-atenolol: estimation of in vivo affinity for the beta1-adrenoceptor with an agonist-antagonist interaction model, J Pharmacol Exp Ther., 324(3): 1234-1242., 2008. [Link to publication]
Danhof M., Lange E.C.d, Della Pasqua O.E., Ploeger B.A. and Voskuyl R.A., Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research, Trends Pharmacol Sci., 29(4): 186-191., 2008. [Link to publication]
Steeg T.J.v., Freijer J., Danhof M. and Lange E.C.d, Pharmacokinetic-pharmacodynamic modelling of S(-)-atenolol in rats: reduction of isoprenaline-induced tachycardia as a continuous pharmacodynamic endpoint, Br J Pharmacol, 10: 10, 2007. [Link to publication]
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