Publications & Presentations in the therapeutic area :

Mechanistic model for the acute effect of fluvoxamine on 5-HT and 5-HIAA concentrations

Geldof M., Freijer J.I., Peletier L.A., Beijsterveldt L.v. and Danhof M., Mechanistic model for the acute effect of fluvoxamine on 5-HT and 5-HIAA concentrations in rat frontal cortex, Eur J Pharm Sci., 33(3): 217-229. Epub 2007 Dec 2007., 2008. [Link to publication]

Pharmacokinetic modeling of non-linear brain distribution of fluvoxamine in the rat

Geldof M., Freijer J., Beijsterveldt L.v. and Danhof M., Pharmacokinetic modeling of non-linear brain distribution of fluvoxamine in the rat, Pharm Res., 25(4): 792-804. Epub 2007 Aug 2021., 2008. [Link to publication]

Amoxicillin pharmacokinetics in pregnant women

Muller A.E., Jongh J.d., Oostvogel P.M., Voskuyl R.A., Dorr P.J., Danhof M. and Mouton J.W., Amoxicillin pharmacokinetics in pregnant women with preterm premature rupture of the membranes, Am J Obstet Gynecol, 198(1): 108 e101-106, 2008. [Link to publication]

The influence of labour on the pharmacokinetics of intravenously administered amoxicillin in pregnant women

Muller A.E., Dorr P.J., Mouton J.W., Jongh J.d., Oostvogel P.M., Steegers E.A., Voskuyl R.A. and Danhof M., The influence of labour on the pharmacokinetics of intravenously administered amoxicillin in pregnant women, Br J Clin Pharmacol., 66(6): 866-874., 2008. [Link to publication]

Extensions to the visual predictive check to facilitate model performance evaluation,

Post T.M., Freijer J.I., Ploeger B.A. and Danhof M., Extensions to the visual predictive check to facilitate model performance evaluation, J Pharmacokinet Pharmacodyn., 35(2): 185-202. 2008. [Link to publication]

Utility of a mixed effects approach to defining target binding rate constants

Benson N., Snelder N., Ploeger B., Napier C., Sale H. and Graaf P.v.d., Utility of a mixed effects approach to defining target binding rate constants. PAGE.(2007). [Link to publication].

Disease system analysis distinguishing disease status from disease process

Jongh J.d., Post T., Freijer J., Winter W.d., Danhof M. and Ploeger B., Disease system analysis distinguishing disease status from disease process. PSWC.(2007).

Population PK/PD analysis of compound X to find appropriate dosage regimen in clinical trial

Funaki T., Post T., Maune H. and Drenth H.,  Population PK/PD analysis of compound X to find appropriate dosage regimen in clinical trial. PAGE. (2007).

Circadian rhythm in pharmacodynamics and its influence on the identification of treatment effects

Post T., Funaki T., Maune H. and Drenth H., Circadian rhythm in pharmacodynamics and its influence on the identification of treatment effects. PAGE.(2007). [Link to publication]

Application of the convection-dispersion equation to modelling oral drug absorption

Freijer J.I., Post T.M., Ploeger B.A., Jongh J.d. and Danhof M., Application of the convection-dispersion equation to modelling oral drug absorption, Bull Math Biol., 69(1): 181-195., 2007. [Link to publication]