Publications

Assessment of the Potential for Displacement Interactions with Sugammadex

Zwiers A., Heuvel M.v.d., Smeets J. and Rutherford S., Assessment of the Potential for Displacement Interactions with Sugammadex: A Pharmacokinetic-Pharmacodynamic Modelling Approach, Clin Drug Investig, 10(10): 11584730-000000000, 2010. [Link to publication]

Effect of altered AGP plasma binding

Steeg T.J.v., Krekels E.H., Freijer J., Danhof M. and Lange E.C.d., Effect of altered AGP plasma binding on heart rate changes by S(-)-propranolol in rats using mechanism-based estimations of in vivo receptor affinity (K(B,vivo)), J Pharm Sci., 99(5): 2511-2520., 2010. [Link to publication]

Marginal increase of sunitinib exposure

Erp N.P.v., Baker S.D., Zandvliet A.S., Ploeger B.A., Hollander M.d., Chen Z., Hartigh J.d., Konig-Quartel J.M., Guchelaar H.J. and Gelderblom H., Marginal increase of sunitinib exposure by grapefruit juice, Cancer Chemother Pharmacol, 29: 29, 2010.

Estimation of binding rate constants

Benson N., Snelder N., Ploeger B., Napier C., Sale H., Birdsall N.J., Butt R.P. and  Graaf P.H.v.d., Estimation of binding rate constants using a simultaneous mixed-effects method: application to monoamine transporter reuptake inhibitor reboxetine, Br J Pharmacol., 160(2): 389-398., 2010. [Link to publication]

Modeling of alpha interferon response

Benson N., Jongh J.d, Duckworth J.D., Jones H.M., Pertinez H.E., Rawal J.K., Steeg T.J. v. and Graaf P.H.v.d., Pharmacokinetic-pharmacodynamic modeling of alpha interferon response induced by a Toll-like 7 receptor agonist in mice, Antimicrob Agents Chemother., 54(3): 1179-1185. 2010. [Link to publication]

Clinical Trial Simulation

Holford N., Ma S.C., and Ploeger B.A. Clinical Trial Simulation: A Review, Clin Pharmacol Ther. 7:7, 2010. [Link to publication]

Pharmacokinetics of clindamycin in pregnant women

Muller A.E., Mouton J.W., Oostvogel P.M., Dorr P.J., Voskuyl R.A., Jongh J.d., Steegers E.A. and Danhof M., The pharmacokinetics of clindamycin in pregnant women in the peripartum period, Antimicrob Agents Chemother, 2010. [Link to publication]

Static allodynia response to pregabalin and sildenafil

Bender G., Florian J.A., Jr., Bramwell S., Field M.J., Tan K.K., Marshall S., Jongh J.d, Bies R.R. and Danhof M., Pharmacokinetic-pharmacodynamic analysis of the static allodynia response to pregabalin and sildenafil in a rat model of neuropathic pain, J Pharmacol Exp Ther., 334(2): 599-608. Epub 2010 May 2015., 2010. [Link to publication]

Explaining variability in ciclosporin exposure

Press R.R., Ploeger B.A., Hartigh J.d, Straaten T.v.d., van Pelt H., Danhof M., Fijter H.d. and Guchelaar H.J., Explaining variability in ciclosporin exposure in adult kidney transplant recipients, Eur J Clin Pharmacol., 66(6): 579-590. Epub 2010 Mar 2031., 2010. [Link to publication]

Pharmacokinetics of amoxicillin

Muller A.E., Oostvogel P.M., Jongh J.d., Mouton J.W., Steegers E.A., Dorr P.J., Danhof M. and Voskuyl R.A., Pharmacokinetics of amoxicillin in maternal, umbilical cord, and neonatal sera, Antimicrob Agents Chemother, 53(4): 1574-1580, 2009. [Link to publication]