Maanen E.v., Steeg T.v., Stone J., Dobrowolska J., Michener M., Savage M., Kennedy M., Bateman R., Kleijn H. and Danhof M., Integrating tracer kinetic data with absolute protein concentration measurements in a systems pharmacology model. Application to the APP pathway in CMP rhesus monkeys., PAGE.(2014) [Link to publication]
Ackaert O., Steeg T.v., Hannesdottir K., Alexander R., Raudibaugh K., Kugler A. and Vis P., Quantification of the effect of AZD5213 on sleep in patients with Alzheimer’s disease or mild cognitive impairment using a two-state Markov model. PAGE.(2014) [Link to publication]
Maanen E.v., Steeg T.v., Ahsman M., Savage M.J., Michener M.S., Kleijn H.J., Danhof M. and Stone J., A systems pharmacology model of the APP processing pathway in Alzheimer’s Disease. ACoP.(2013) [Link to publication]
Hannesdottir K., Minkwitz M., Raudibaugh K., Vis P., Ackaert O. and Alexander R. A Phase 2 Safety and Tolerability Study to Investigate the Effect of AZD5213 on Sleep in Subjects with Mild Cognitive Impairment and Mild Alzheimer’s Disease. AAIC (2013)
Westerhout J., Smeets J., Danhof M. and de Lange E.C., The impact of P-gp functionality on non-steady state relationships between CSF and brain extracellular fluid, J Pharmacokinet Pharmacodyn, 29: 29, 2013. [Link to publication]
Diack C., Ackaert O., Ploeger B.A., Graaf P.H.v.d., R.Gurrel, Ivarsson M. and Fairman D., A hidden Markov model to assess drug-induced sleep fragmentation. PAGE.(2012) [Link to publication]
Wallsten C., Ackaert O., Ekerot P., Snelder N., Quirk M., Fonck C. and Ploeger B., Quantification of the Drug Effect and Exploration of Mechanism of Action of Two NMDA Channel Blockers, AZD6765 and Ketamine, Using Mouse EEG Data PAGE.(2012) [Link to publication]
Stone J.A., Maanen E.v., Ahsman M., Steeg T.v., Savage M.J., Michener M.S. and Kleijn H., An Integrated Mechanistic Model to Interrelate CSF Aβ40, Aβ42, sAPPβ, and sAPPα Response to β and γ-secretase Inhibitors in Rhesus Monkey. AAIC.(2012)
Maanen E.v., Stone J.A., Steeg T.v., Ahsman M., Savage M.J., Michener M.S. and Kleijn H., A step-wise analysis of multiple biomarkers drives the development of a Semi-Mechanistic Comprehensive Model. Application to modulation of Amyloid-β. PAGE.(2012) [Link to publication]
Bergmann K., Ackaert O., Maanen E.v., Snelder N., Maciag C., Quirk M., Wallsten C. and Ploeger B., Quantification of Antidepressant and Sedative Effect of Two NMDA Channel Blockers, AZD6765 and Ketamine, in an Animal Model of Depression Using Count Data. PAGE.(2012)
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