Archive for December 2009
Effect of altered AGP plasma binding on heart rate changes
Steeg T.J.v., Krekels E.H., Freijer J., Danhof M. and Lange E.C.d., Effect of altered AGP plasma binding on heart rate changes by S(-)-propranolol in rats using mechanism-based estimations of in vivo receptor affinity (K(B,vivo)), J Pharm Sci, 17: 17, 2009. [Link to publication]
Read MoreInfluence of plasma protein binding on pharmacodynamics
Steeg T.J.v., Boralli V.B., Krekels E.H., Slijkerman P., Freijer J., Danhof M. and Lange E.C.d., Influence of plasma protein binding on pharmacodynamics: Estimation of in vivo receptor affinities of beta blockers using a new mechanism-based PK-PD modelling approach, J Pharm Sci., 98(10): 3816-3828., 2009. [Link to publication]
Read MoreExplaining variability in tacrolimus pharmacokinetics
Press R.R., Ploeger B.A., Hartigh J. d, Straaten T.v.d., Pelt J.v., Danhof M., Fijter J.W.d and Guchelaar H.J., Explaining variability in tacrolimus pharmacokinetics to optimize early exposure in adult kidney transplant recipients, Ther Drug Monit., 31(2): 187-197., 2009. [Link to publication]
Read MoreReversal of neuromuscular blockade
Ploeger B.A., Smeets J., Strougo A., Drenth H.J., Ruigt G., Houwing N. and Danhof M., Pharmacokinetic-pharmacodynamic model for the reversal of neuromuscular blockade by sugammadex, Anesthesiology., 110(1): 95-105., 2009. [Link to publication]
Read MoreWashout and delayed start designs for identifying disease modifying effects
Ploeger B.A. and Holford N.H., Washout and delayed start designs for identifying disease modifying effects in slowly progressive diseases using disease progression analysis, Pharm Stat., 8(3): 225-238., 2009. [Link to publication]
Read MoreIncorporating receptor theory
Ploeger B.A., Graaf P.H.v.d and Danhof M., Incorporating receptor theory in mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling, Drug Metab Pharmacokinet., 24(1): 3-15., 2009. [Link to publication]
Read MoreChanges in GABAA receptor properties in amygdala kindled animals
Liefaard L.C., Ploeger B.A., Molthoff C.F., Jong H.W.d, Dijkstra J., Weerd L.v.d., Lammertsma A.A., Danhof M. and Voskuyl R.A., Changes in GABAA receptor properties in amygdala kindled animals: in vivo studies using [11C]flumazenil and positron emission tomography, Epilepsia., 50(1): 88-98., 2009. [Link to publication]
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