Archive for December 2015
PKPD modelling of the relationship between testosterone and PSA
Snelder N., Drenth H., Bergmann K., Wood N., Hibberd M. and Scott G., PKPD modelling of the relationship between testosterone and PSA in patients with prostate cancer during treatment with leuprorelin. What is the optimal testosterone level?, PAGE.(2015) [Link to publication]
Read MoreA mechanism-based model is able to simultaneously explain the effect of rhLCAT and HDL mimetics on biomarkers of reverse cholesterol transport
Bosch R., K.Bergmann, Baverel P., Fairman D., Vis P. and Agoram B., A mechanism-based model is able to simultaneously explain the effect of rhLCAT and HDL mimetics on biomarkers of reverse cholesterol transport. PAGE.(2015) [Link to publication]
Read MoreApplication of a Semi-Mechanistic, Integrated Glucose-Insulin Model to Graded Glucose Infusion Placebo Data
Bosch R., Gao W., Vargo R., Baliathan C., Fancourt C., Kothare P.A., Kjellson M.C., Karlsson M. and Post T., Application of a Semi-Mechanistic, Integrated Glucose-Insulin Model to Graded Glucose Infusion Placebo Data to translate Glucose Insulin dynamics between Healthy Humans and Non-Human Primates. PAGE.(2015) [Link to publication]
Read MoreRecombinant Antithrombin (ATryn) to achieve >80% AT activity in pediatric and neonatal ECMO patients
DeJongh J., Streisand J., Todd Tzanetos D., Fanning J. and Drenth H., Recombinant Antithrombin (ATryn) to achieve >80% AT activity in pediatric and neonatal ECMO patients. 26th Annual ELSO Conference.(2015) [Link to publication]
Read MoreApplication of a Systems Pharmacology-Based Placebo Population Model to Analyze Long-Term Data of Postmenopausal Osteoporosis
Berkhout J., Stone J.A., Verhamme K.M., Stricker B.H., Sturkenboom M.C., Danhof M. and Post T.M., Application of a Systems Pharmacology-Based Placebo Population Model to Analyze Long-Term Data of Postmenopausal Osteoporosis, CPT Pharmacometrics Syst Pharmacol., 4(9): 516-526. doi: 510.1002/psp1004.12006. Epub 12015 Aug 12022., 2015. [Link to publication]
Read MoreModel-Based Once-Daily Darunavir/Ritonavir Dosing Recommendations
Brochot A., Kakuda T.N., Van De Casteele T., Opsomer M., Tomaka F.L., Vermeulen A. and Vis P., Model-Based Once-Daily Darunavir/Ritonavir Dosing Recommendations in Pediatric HIV-1-Infected Patients Aged >/=3 to <12 Years, CPT Pharmacometrics Syst Pharmacol., 4(7): 406-414. doi: 410.1002/psp1004.1044. Epub 2015 Jun 1019., 2015. [Link to publication]
Read MoreDose Selection of Antithrombin (Recombinant)
Paidas M.J., Frieling J., de Jongh J., Drenth H.J. and Streisand J., Dose Selection of Antithrombin (Recombinant) for a Phase 3 Trial in Early-Onset Preeclampsia [149], Obstet Gynecol., 125(Suppl 1): 52S., 2015. [Link to publication]
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