Archive for December 2011
Population modeling of blood pressure
Ackaert O., Rijn-Bikker P.v., Snelder N., Hest R.v., Ploeger B., Monfrans G.v., Koopmans R. and Mathot R., Population modeling of blood pressure: assessing clinically important factors for cardiovascular diseases. PAGE.(2011) [Link to publication]
Read MoreQuantitative understanding of drug effects on the interrelationship between mean arterial blood pressure, cardiac output and total peripheral resistance
Snelder N., Ploeger B.A., Danhof M., Stanski D.R., Rigel D., Webb R., Feldman D. and Luttringer O., Quantitative understanding of drug effects on the interrelationship between mean arterial blood pressure, cardiac output and total peripheral resistance. PAGE.(2011) [Link to publication]
Read MoreChallenges in Non-Clinical Assessment of Antisense Oligonucleotides
Maanen E.V., Challenges in Non-Clinical Assessment of Antisense Oligonucleotides: Modelling Perspectives. AAPS (National Biotechnology Conference).(2011)
Read MoreDrug-induced sleep fragmentation
Diack C., Ackaert O., Ploeger B.A., Graaf P.H.v.d., Gurrell R., Ivarsson M. and Fairman D., A hidden Markov model to assess drug-induced sleep fragmentation in the telemetered rat, J Pharmacokinet Pharmacodyn, 10: 10, 2011. [Link to publication]
Read MoreMorphine and its metabolites
Krekels E.H., Jongh J.d., Lingen R.A.v., Marel C.D.v.d., Choonara I., Lynn A.M., Danhof M., Tibboel D. and Knibbe C.A., Predictive performance of a recently developed population pharmacokinetic model for morphine and its metabolites in new datasets of (preterm) neonates, infants and children, Clin Pharmacokinet., 50(1): 51-63, 2011. [Link to publication]
Read More