Archive for December 2008
A Mechanism-based Pharmacokinetic Model Describing the Interaction Between Sugammadex and Rocuronium in Patients with Normal and Impaired Renal Function
Smeets J., Ploeger B., Strougo A., Liefaard L. and Kerbusch T., A Mechanism-based Pharmacokinetic Model Describing the Interaction Between Sugammadex and Rocuronium in Patients with Normal and Impaired Renal Function. PAGE.(2008). [Link to publication]
Read MoreImplementing receptor theory in PK-PD modeling
Danhof M. and Ploeger B., Implementing receptor theory in PK-PD modeling. PAGE.(2008). [Link to publication]
Read MoreAre Wash-Out Designs Better than Delayed Start Designs?
Ploeger B. and Holford N.H., Are Wash-Out Designs Better than Delayed Start Designs? ACOP.(2008).
Read MoreAssessment of the use of complex baseline models in preclinical safety screening
Steeg T. v., Strougo A., Ploeger B. and Graaf P. v. d., Assessment of the use of complex baseline models in preclinical safety screening: Application of the van der Pol oscillator model to describe heart rate effects in rats. PAGE.(2008). [Link to publication]
Read MorePharmacokinetic-pharmacodynamic modelling of fluvoxamine 5-HT transporter occupancy in rat frontal cortex
Geldof M., Freijer J.I., Beijsterveldt L.v., Langlois X. and Danhof M., Pharmacokinetic-pharmacodynamic modelling of fluvoxamine 5-HT transporter occupancy in rat frontal cortex, Br J Pharmacol., 154(6): 1369-1378. Epub 2008 May 1319., 2008. [Link to publication]
Read MoreMechanistic model for the acute effect of fluvoxamine on 5-HT and 5-HIAA concentrations
Geldof M., Freijer J.I., Peletier L.A., Beijsterveldt L.v. and Danhof M., Mechanistic model for the acute effect of fluvoxamine on 5-HT and 5-HIAA concentrations in rat frontal cortex, Eur J Pharm Sci., 33(3): 217-229. Epub 2007 Dec 2007., 2008. [Link to publication]
Read MorePharmacokinetic modeling of non-linear brain distribution of fluvoxamine in the rat
Geldof M., Freijer J., Beijsterveldt L.v. and Danhof M., Pharmacokinetic modeling of non-linear brain distribution of fluvoxamine in the rat, Pharm Res., 25(4): 792-804. Epub 2007 Aug 2021., 2008. [Link to publication]
Read MoreAmoxicillin pharmacokinetics in pregnant women
Muller A.E., Jongh J.d., Oostvogel P.M., Voskuyl R.A., Dorr P.J., Danhof M. and Mouton J.W., Amoxicillin pharmacokinetics in pregnant women with preterm premature rupture of the membranes, Am J Obstet Gynecol, 198(1): 108 e101-106, 2008. [Link to publication]
Read MoreMechanism-based pharmacodynamic modeling of S(-)-atenolol
Steeg T.J.v., Freijer J., Danhof M. and Lange E. C. d., Mechanism-based pharmacodynamic modeling of S(-)-atenolol: estimation of in vivo affinity for the beta1-adrenoceptor with an agonist-antagonist interaction model, J Pharmacol Exp Ther., 324(3): 1234-1242., 2008. [Link to publication]
Read MoreThe influence of labour on the pharmacokinetics of intravenously administered amoxicillin in pregnant women
Muller A.E., Dorr P.J., Mouton J.W., Jongh J.d., Oostvogel P.M., Steegers E.A., Voskuyl R.A.and Danhof M., The influence of labour on the pharmacokinetics of intravenously administered amoxicillin in pregnant women, Br J Clin Pharmacol., 66(6): 866-874., 2008. [Link to publication]
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