Archive for July 2017
A systems pharmacology approach unfolds Aβ oligomer modulation
Maanen E.M.T.v., Steeg T.J.v., Kalinina J., Michener M.S., Savage, M.J., Kennedy M.E., Parker E.M., Danhof, M. A systems pharmacology approach unfolds Aβ oligomer modulation and unravels the dynamics of the APP pathway. Page 2017. [Link to publication]
Read MoreResilience in the Amyloid Precursor Protein ( APP ) pathway revealed
Maanen E.M.T., Steeg, TJ.v., Kalinina J., Stone, J., Michener M.S., Savage M.J., Parker E.M., Danhof, M. Resilience in the Amyloid Precursor Protein ( APP ) pathway revealed by systems pharmacology modeling following β – and γ -secretase inhibition. AAIC, 2017.
Read MoreImpact of acute fat mobilisation on the pharmacokinetics of the highly fat distributed compound TAK-357, investigated by physiologically based pharmacokinetic (PBPK) modeling and simulation
Goto, A., Tagawa, Y., Moriya, Y., Sato, S., Furukawa, Y., Wakabayashi, T., Tsukamoto T., Jongh J.d, Steeg T.J.v., Moriwaki T., Asahi, S. Impact of acute fat mobilisation on the pharmacokinetics of the highly fat distributed compound TAK-357, investigated by physiologically based pharmacokinetic (PBPK) modeling and simulation. Biopharmaceutics & Drug Disposition, 373–380, 2017. [Link to publication]
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