Archive for December 2012
A hidden Markov model to assess drug-induced sleep fragmentation
Diack C., Ackaert O., Ploeger B.A., Graaf P.H.v.d., R.Gurrel, Ivarsson M. and Fairman D., A hidden Markov model to assess drug-induced sleep fragmentation. PAGE.(2012) [Link to publication]
Read MoreQuantification of the Drug Effect and Exploration of Mechanism of Action of Two NMDA Channel Blockers
Wallsten C., Ackaert O., Ekerot P., Snelder N., Quirk M., Fonck C. and Ploeger B., Quantification of the Drug Effect and Exploration of Mechanism of Action of Two NMDA Channel Blockers, AZD6765 and Ketamine, Using Mouse EEG Data PAGE.(2012) [Link to publication]
Read MoreAn Integrated Mechanistic Model
Stone J.A., Maanen E.v., Ahsman M., Steeg T.v., Savage M.J., Michener M.S. and Kleijn H., An Integrated Mechanistic Model to Interrelate CSF Aβ40, Aβ42, sAPPβ, and sAPPα Response to β and γ-secretase Inhibitors in Rhesus Monkey. AAIC.(2012)
Read MoreA step-wise analysis of multiple biomarkers drives the development of a Semi-Mechanistic Comprehensive Model. Application to modulation of Amyloid-β
Maanen E.v., Stone J.A., Steeg T.v., Ahsman M., Savage M.J., Michener M.S. and Kleijn H., A step-wise analysis of multiple biomarkers drives the development of a Semi-Mechanistic Comprehensive Model. Application to modulation of Amyloid-β. PAGE.(2012) [Link to publication]
Read MoreData transformation procedure to improve identifiability of efficacy and potency
Maanen E.v., Ackaert O., Snelder N., Bergmann K., Maciag C., Quirk M., Wallsten C. and Ploeger B., Data transformation procedure to improve identifiability of efficacy and potency: Application to continuous elevated plus-maze data in rats., PAGE.(2012) [Link to publication]
Read MoreDevelopment of a mechanistic based model for neonatal Fc receptor recycling to design human serum albumin mutants with extended half-lives
Bergmann K., Steeg T.v., Smeets J., Chaudhury C. and Agoram B., Development of a mechanistic based model for neonatal Fc receptor recycling to design human serum albumin mutants with extended half-lives PAGE.(2012) [Link to publication]
Read MoreQuantification of Antidepressant and Sedative Effect of Two NMDA Channel Blockers
Bergmann K., Ackaert O., Maanen E.v., Snelder N., Maciag C., Quirk M., Wallsten C. and Ploeger B., Quantification of Antidepressant and Sedative Effect of Two NMDA Channel Blockers, AZD6765 and Ketamine, in an Animal Model of Depression Using Count Data. PAGE.(2012)
Read MoreComparing a mechanistic with an empirical approach to assess resistance development of antibacterials in vitro
Bergmann K., Ackaert O., Haddish-Berhane N. and Betts A., Comparing a mechanistic with an empirical approach to assess resistance development of antibacterials in vitro., PAGE.(2012) [Link to publication]
Read MoreAcute dopamine inhibition challenge
Stevens J., Ploeger B.A., Hammarlund-Udenaes M., Osswald G., van der Graaf P.H., Danhof M. and de Lange E.C., Mechanism-based PK-PD model for the prolactin biological system response following an acute dopamine inhibition challenge: quantitative extrapolation to humans, J Pharmacokinet Pharmacodyn., 39(5): 463-477. doi: 410.1007/s10928-10012-19262-10924. Epub 12012 Jul 10912., 2012. [Link to publication]
Read MoreRegional brain distribution kinetics in rats
Westerhout J., Ploeger B., Smeets J., Danhof M. and de Lange E.C., Physiologically based pharmacokinetic modeling to investigate regional brain distribution kinetics in rats, Aaps J., 14(3): 543-553. doi: 510.1208/s12248-12012-19366-12241. Epub 12012 May 12217., 2012. [Link to publication]
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