Archive for December 2013
The impact of P-gp functionality
Westerhout J., Smeets J., Danhof M. and de Lange E.C., The impact of P-gp functionality on non-steady state relationships between CSF and brain extracellular fluid, J Pharmacokinet Pharmacodyn, 29: 29, 2013. [Link to publication]
Read MoreCharacterisation of the pharmacokinetics of ethinylestradiol and drospirenone
Reif S., Snelder N. and Blode H., Characterisation of the pharmacokinetics of ethinylestradiol and drospirenone in extended-cycle regimens: population pharmacokinetic analysis from a randomised Phase III study, J Fam Plann Reprod Health Care., 39(2): e1. doi: 10.1136/jfprhc-2012-100397., 2013. [Link to publication]
Read MorePKPD modelling of the interrelationship
Snelder N., Ploeger B.A., Luttringer O., Rigel D.F., Webb R.L., Feldman D., Fu F., Beil M., Jin L., Stanski D.R. and Danhof M., PKPD modelling of the interrelationship between mean arterial BP, cardiac output and total peripheral resistance in conscious rats, Br J Pharmacol., 169(7): 1510-1524. doi: 1510.1111/bph.12190., 2013. [Link to publication]
Read MoreEvaluation of the Impact of UGT Polymorphism
Stringer F., Ploeger B.A., Jongh J.d., Scott G., Urquhart R., Karim A. and Danhof M., Evaluation of the Impact of UGT Polymorphism on the Pharmacokinetics and Pharmacodynamics of the Novel PPAR Agonist Sipoglitazar, J Clin Pharmacol., 53(3): 256-263, 2013. [Link to publication]
Read MoreNonlinear mixed effects modeling of the diurnal blood pressure profile
van Rijn-Bikker P.C., Snelder N., Ackaert O., van Hest R.M., Ploeger B.A., van Montfrans G.A., Koopmans R.P. and Mathot R.A., Nonlinear mixed effects modeling of the diurnal blood pressure profile in a multiracial population, Am J Hypertens., 26(9): 1103-1113. doi: 1110.1093/ajh/hpt1088., 2013. [Link to publication]
Read MoreA model-based approach to analyze the influence of UGT2B15
Stringer F., Dejongh J., Scott G. and Danhof M., A model-based approach to analyze the influence of UGT2B15 polymorphism driven pharmacokinetic differences on the pharmacodynamic response of the PPAR agonist sipoglitazar, J Clin Pharmacol, 11(10): 227, 2013. [Link to publication]
Read MorePharmacokinetics of Recombinant Human Antithrombin
Dejongh J., Frieling J., Lowry S. and Drenth H.J., Pharmacokinetics of Recombinant Human Antithrombin in Delivery and Surgery Patients With Hereditary Antithrombin Deficiency, Clin Appl Thromb Hemost, 11: 11, 2013. [Link to publication]
Read MoreApplication of M&S for Bispecifics in early discorvery.
Steeg T.v., Bergmann K., agoram B. and Sachsenmeier K., Application of M&S for Bispecifics in early discorvery. PKPK of novel constructs.(2013)
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